Publications Before 2011


Dong, Guangbin; Teo, Peili; Wickens, Zachary, K.; Grubbs, Robert H.* “Primary Alcohols from Terminal Olefins: Formal Anti-Markovnikov Hydration-like Process via Triple Relay Catalysis” Science2011, 333(6049), 1609-1612. [doi]

*Highlighted by Chemical & Engineering News, 89(38), September 19, 2011
Rule breaking Leads to Primary Alcohols. “One-pot reaction circumvents classic tenet governing additions to double bonds” By linking three processes in one pot, chemists have taken a step toward a greener alternative to hydroboration/oxidation, the classic two-step method for forming primary alcohols from alkenes (Science, DOI: 10.1126/science.1208685 To find a catalytic alternative, Caltech’s Robert H. Grubbs , Guangbin Dong , Peili Teo, and Zachary K. Wickens had to override Markovnikov’s rule, which dictates that a proton should end up on the less substituted alkene carbon, forming a secondary alcohol instead of the desired primary alcohol.
*Highlighted by CHEMCATCHEM, DOI: 10.1002/cctc.201100407

The search for anti-Markovnikov: The catalytic anti-Markovnikov hydration of terminal alkenes: how can it be done? Robert H. Grubbs et al. have partially answered this question. To design multiple coupled catalytic cycles is a complex endeavor, which is discussed here in the context of recent results. Increasingly mild coupled redox reactions look to help solve this intrinsic problem.


Trost, Barry M.;* Ngai, Ming-Yu; Dong, Guangbin “Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents” Organic Letters201113, 1900-1903. [doi]


Trost, Barry M.;* Frontier, Alison J.; Thiel, Oliver R.; Yang, Hanbiao; Dong, Guangbin “Total Syntheses of Bryostatins. Methods Developments: Atom-Economic and Stereoselective Synthesis of C-ring Subunit” Chemistry - A European Journal201117, 9762-9776. [doi]


Trost, Barry M.;* Yang, Hanbiao; Brindle, Cheyenne S.; Dong, Guangbin “Atom-Economic and Stereoselective Syntheses of the Ring A and B Subunits of the Bryostatins” Chemistry - A European Journal201117, 9777-9788. [doi]


Trost, Barry M.;* Yang, Hanbiao, Dong, Guangbin “Total Syntheses of Bryostatins. Syntheses of Two Ring-Expanded Bryostatin Analogues and Development of a New-Generation Strategy to Access the C7-C27 Fragment” Chemistry - A European Journal201117, 9789-9805. [doi]


Trost, Barry M.;* Dong, Guangbin “Total Synthesis of Bryostatin 16 using a Pd-Catalyzed Diyne-coupling as Macrocyclization Method and Synthesis of C20-epi-Bryostatin 7 as a Potent Anticancer Agent” Journal of the American Chemical Society2010132, 16403–16416. [doi]


Dong, Guangbin* “A Historical Story on the Synthesis of Agelastatin” Pure and Applied Chemistry201082, 2231-2246 (2010 IUPAC Prize for Young Chemists, invited review). [doi]


Trost, Barry M.;* Osipov, Maksim; Dong, Guangbin “Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Vinyl Aziridines with Nitrogen Heterocycles: Rapid Access to Biologically Active Pyrroles and Indoles” Journal of the American Chemical Society2010132, 15800–15807. [doi]


Trost, Barry M.;* Osipov, Maksim; Dong, Guangbin “A Concise Enantioselective Synthesis of (–)- Ranirestat.” Organic Letters201012, 1276-1279. [doi]


Trost, Barry M.;* Dong, Guangbin; Vance, Jennifer A. “Cyclic 1,2-Diketones as Core Building Blocks: A Strategy for the Total Synthesis of (–)-Terpestacin.” Chemistry - A European Journal201016, 6265-6277. [doi]


Trost, Barry M.;* Dong, Guangbin “A Stereodivergent Strategy to Both Product Enantiomers from the Same Enantiomer of A Stereoinducing Catalyst: Agelastatin A.” Chemistry - A European Journal200915, 6910-6919. [doi]


Trost, Barry M.;* Dong, Guangbin “Total Synthesis of Bryostatin 16 Using Atom Economical and Chemoselective Approaches.” Nature2008456, 485-488. [doi]

Highlighted by Angewandte Chemie International Edition (200948, 3221-3223) [doi]Chemical and Engineering News(20088, 11) [doi], Chemistry World of Royal Chemical Society (200827 November) and Nature (2008456, 451-453.)[doi]


Dong, Guangbin* “Hosomi–Sakurai Reaction” Vol. 3, 139-180; Modern Organic Reactions, Hu, Yuefei; Lin, Guoqiang Eds, Chemical Industry Press: Beijing, 2008.


Trost, Barry M.;* Dong, Guangbin “Asymmetric Annulation toward Pyrrolo-piperazinones. Concise Enantioselective Syntheses of Pyrrole Alkaloid Natural Products.” Organic Letters20079, 2357-2359. [doi]


Trost, Barry M.;* Dong, Guangbin; Vance, Jennifer A. “A Diosphenol-Based Strategy for the Total Synthesis of (–)-Terpestacin.” Journal of the American Chemical Society2007129, 4540-4541. [doi]


Trost, Barry M.;* Dong, Guangbin “New Class of Nucleophiles for Palladium-Catalyzed Asymmetric Allylic Alkylation. Total Synthesis of Agelastatin A.” Journal of the American Chemical Society2006128, 6054-6055. [doi]


Tang, Yefeng; Deng, Lujiang; Zhang, Yandong; Dong, Guangbin; Chen, Jiahua;* Yang, Zhen* “Thioureas as Ligands in the Pd-Catalyzed Intramolecular Pauson-Khand Reaction.” Organic Letters20057, 1657-1659. [doi]


Tang, Yefeng; Deng, Lujiang; Zhang, Yandong; Dong, Guangbin; Chen, Jiahua;* Yang, Zhen* “Tetramethyl Thiourea/Co2(CO)8-Catalyzed Pauson-Khand Reaction under Balloon Pressure of CO.” Organic Letters20057, 593-595. [doi]


Dai, Mingji; Liang, Bo; Wang, Cuihua; You, Zejin; Xiang, Jing; Dong, Guangbin; Chen, Jiahua;* Yang, Zhen* “A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions.” Advanced Synthesis & Catalysis 2004346, 1669-1673. [doi]


Dai, Mingji; Wang, Cuihua; Dong, Guangbin; Xiang, Jing; Luo, Tuoping; Liang, Bo; Chen, Jiahua;* Yang, Zhen* “Development of Thiourea-based Ligands for the Pd-Catalyzed Bis(methoxy -carbonylation) of Terminal Olefins.”European Journal of Organic Chemistry200322, 4346-4348. [doi] 
* corresponding author